NMN 12000

ENC NMN

Rebirth against age

 

Main raw materials/Ingredients:

Sorbitol, ginseng (5 years ginseng, artificially grown), bird’s nest, truffle, Haematococcus pluvialis, grapes, pomegranate, yeast powder, γ-aminobutyric acid, phosphatidylserine, edamame, broccoli, cabbage, Avocado, Tomato, Agaricus bisporus, Blueberry

 

Product content：

Each tablet contains 150mg of beta-Nicotinamide Mononucleotide, 50mg of phosphatidylserine, 30mg of γ-aminobutyric acid, 10mg of resveratrol, 5mg of astaxanthin, 2mg of ginseng (5 years ginseng, artificially grown), 2mg of bird’s nest, 2mg of truffle

 

Product specifications:

0.81 g x 80 tablets

 

Directions:

Taking 2-3 tablets per day (Adults only)

 

Storage Method:

Store in a cool dry place, refrigerate after opening.

 

Great and Suitable for:

1. Middle-aged and elderly people (used to assist in improving various sub-health and aged diseases)
2. Adults who are under high pressure, seriously overdrawn, often stay up late, prone to fatigue, etc.
3. People with poor mental state: nervousness, depression, poor memory, insomnia, etc.
4. People with poor skin that hope to improve skin complexion and delay skin senescence.

 

Product Features:

The high content of NMN extracted from a variety of natural vegetable and mushrooms which combined with a variety of plant essence ingredients can effectively anti-inflammatory, antioxidant, anti-aging, prevent brain atrophy, prevent memory deterioration, balance hormone levels, prevent and improve indigestion, etc. It also can maintain the health of the human body in an all-round way, fill the body with energy, and stay young.

 

Nutrition Knowledge:

With the development and progress of life sciences, human finally realised that the essential cause of aging is the gene carriers in cells: DNA and energy factories. Mitochondria will gradually accumulate damage with the age while the self-repair ability of cells will decrease. At the same time, external factors such as environmental pollution, drugs, and radiation will further accelerate gene damage and accelerate the aging process.

NMN was discovered by British biologists as early as 1904, but it was initially confirmed by David Sinclair’s laboratory at Harvard University until 2014 that it is a precursor of a key coenzyme NAD+ in the body. NAD+ is not only an important raw material for the DNA repair system in the cell, but also a key contact factor between the nucleus and the mitochondria responsible for energy synthesis. At the same time, the NAD+ content in the human body is closely related to the activity of the sirtuins protein family, which has the effects of prolonging lifespan and inhibiting aging.

However, NAD+ cannot be directly absorbed by cells. Therefore, scientists have found the precursor of NAD+ that can be absorbed and utilised by cells—NMN. Oral NMN can quickly reaches to the bloodstream within 10 minutes, and gradually increases the NAD+ level within 30 minutes in the body! NMN can effectively compensate for the decline in NAD+ content in the body caused by aging, and significantly inhibit the decline in metabolism, weight gain and osteoporosis caused as well. In addition, NMN has also been found to effectively prevent retinopathy caused by aging and improve nerve function. These findings make NMN quickly become the focus of research in the field of aging medicine. Nearly a hundred papers published in authoritative academic journals such as Cell, Nature, and Science have detailed its efficacy and mechanism of action. As shown in the latest research report published in Cell (2018) NMN successfully reversed vascular death and muscle atrophy in elderly animals, and greatly enhanced the animals’ exercise endurance. The physical strength and explosive power of the elderly animals which have taken the NMN were 60% higher than those of the same age but have not taken the NMN, and even surpassed the level of youth. The most surprising thing is the recovery of NAD+ brought by oral administration of NMN can extend the lifespan of experimental animals that similar to humans’ system by more than 30%.

From 2016 to 2018, Harvard University, the University of Washington, Keio University and other research institutions from Japan respectively evaluated the anti-aging effect of NMN in detail. Including reversed muscular atrophy and improved physical fitness, inhibiting the cognitive decline caused by aging, the perspectives of reversing vascular death and protecting cardio-cerebrovascular function. The results showed that NMN had a significant effect on all aspects of inhibiting aging.

 

1. What is NMN andNAD+?

NMN stands for nicotinamide mononucleotide, a molecule naturally occurring in all life forms. At the molecular level, it is a ribonucleotide, which is a basic structural unit of nucleic acid RNA. Structurally, the molecule is composed of a nicotinamide group, a ribose, and a phosphate group. NMN is the direct precursor of the essential molecule nicotinamide adenine dinucleotide (NAD+) and is considered a key component to increase NAD+ levels in cells. Although NAD+ is an essential coenzyme required for life and cellular functions. Enzymes are catalysts that make biochemical reactions possible. Coenzymes are ‘helper’ molecules that enzymes need in order to function. The NAD+ molecule itself is too big to totally be degraded in the Gastro-Intestinal tract. Therefore, supplementing with NAD+ itself is ineffective.

NMN enters the body and becomes NAD+, which plays an important role in energy and material metabolism. As far as the tricarboxylic acid cycle is concerned, the tricarboxylic acid cycle is the final metabolic pathway of the human body’s three major nutrients (carbohydrates, lipids, and amino acids). It is also the hub of the metabolic link between carbohydrates, lipids and amino acids. The tricarboxylic acid cycle is at the same time Providing a large amount of energy for the organism is the energy hub of the organism. NAD+ has a fundamental impact on human health, but as the age increases, the content of NAD+ in the human body gradually decreases, and the communication between mitochondria and the nucleus is impaired. So supplementing NMN is the key to maintaining a longevity and youthful body.

2. What are the main functions of NAD+?

1) Aging

NAD+ is the fuel that helps sirtuins sustain genome integrity and promote DNA repair. Like a car cannot drive without fuel, sirtuins’ activation requires NAD+. Results from animal studies showed that raising NAD+ level in the body activates sirtuins and increases the lifespans of yeast, worms and mice. Although animal studies showed promising results in anti-aging properties, scientists are still studying how these results can translate to humans.

2) Metabolic Disorders

NAD+ is one of the keys to maintaining healthy mitochondrial functions and steady energy output. Aging and high-fat diet reduces the level of NAD+ in the body. Studies have shown that taking NAD+ boosters can alleviate diet-associated and age-associated weight gain in mice and improve their exercise capacity, even in aged mice. Other studies even reversed the diabetes effect in female mice, showing new strategies to fight metabolic disorders, such as obesity.

3) Heart Function

Boosting NAD+ levels protect the heart and improves cardiac functions. High blood pressure can cause an enlarged heart and blocked arteries that lead to strokes. In mice, NAD+ boosters have replenished NAD+ levels in the heart and prevented injuries to the heart caused by a lack of blood flow. Other studies have shown that NAD+ boosters can protect mice from abnormal heart enlargement.

4) Neurodegeneration

In mice with Alzheimer’s, raising the NAD+ level can decrease protein build up that disrupts cell communication in the brain to increase cognitive function. Boosting NAD+ levels also protect brain cells from dying when there’s insufficient blood flow to the brain. Many studies in animal models present new prospects of helping the brain age healthily, defending against neurodegeneration and improving memory.

5) Immune System

As adults get older the immune system declines, people get ill more easily, and it becomes harder for people to bounce back from illnesses such as the seasonal flu, or even COVID-19. Recent studies have suggested that NAD+ levels play an important role in regulating inflammation and cell survival during the immune response and aging. The study underscored the therapeutic potential of NAD+ for immune dysfunction.

6) Even can help fight COVID-19

While scientists are in the lab racing time to find a cure for COVID-19, physicians on the front lines running out of options turn to innovative techniques. As a last resort to treat his patients, doctor Robert Huizenga of Cedars Sinai Medical Centre administered an NMN cocktail infused with boosters like zinc to the patient to calm the cytokine storm stirred up by COVID-19. The NMN cocktail brought down the patients’ fever and inflammation levels within 12 hours. During the pandemic, NMN is receiving more and more attention for its role in maintaining the immune system balance, which may be a possible treatment for the coronavirus-caused cytokine storm. With the preliminary studies showing some positive results, although not a guaranteed cure, many scientists and physicians believe the NAD+ booster’s effect on COVID-19 is worth investigating.

3. What raw material is NMN extracted from? Is the source safe and reliable?

There is a certain amount of NMN in a variety of fruits, vegetables, fungi and animals. Through these raw materials (such as truffles, avocados, broccoli, yeast powder, pomegranate, edamame, tomatoes, agaricus bisporus and so on as mentioned in our product) by processing and extraction using American advanced biological enzyme method (a green technology, non-toxic and harmless, equivalent to imitating the working process of catalytic enzymes in the human body) that can be prepared by further separation.

4. What are the main applications of NMN products?

1) Maintaining cellular energy levels at youthful levels. NMN has an important effect on the production of cellular energy.

2) Countering age-related metabolic decline. The effects if NMN supplementation go beyond just the increased production of NAD+.

3) The circulatory system carries blood rich in oxygen, exchanges heat and nutrients, and removes waste from all the organs and systems in the body.

4) Research into the anti-aging properties of NMN shows that the notion of aging being an irreversible process may no longer be an absolute.