Mannaple NMN 18000

Product Content:

Each tablet contains 250mg of NMN, 50mg of citrus bioflavonoids, 50mg of grape seeds, 50mg of vitamin C, 50mg of niacin (B3), 20mg of L-theanine and 20mg of pure Marine collagen peptide powder

Product specification: 72 granules

How to Use: Take one capsule daily (adults only)

Storage method:

Store in a cool dry place, refrigerate after opening.

Very suitable for:

1. Middle-aged and elderly (used to assist in improving various sub-health and senile diseases)

2. Adults who are stressed, overdrawn, often stay up late, easily tired, etc.

3, poor mental state of people: neuroticism, depression, poor memory, insomnia and so on.

4. People with bad skin who want to improve skin tone and delay skin aging.

Product features:

High content of NMN and a variety of plant extracts of the antioxidant, anti-aging, anti-brain atrophy, anti-memory decline and other synergistic effects, can comprehensively maintain human health, make the body full of vitality, keep young state.

Nutrition:

With the development and progress of life science, human beings have finally realized that the root cause of aging is the gene carrier in cells: DNA and energy factory. Mitochondria accumulate damage with age, and the cell’s ability to repair itself decreases. At the same time, environmental pollution, drugs, radiation and other external factors will further accelerate the genetic damage, accelerate the aging process.

NMN was first discovered by British biologists in 1904, but it was only tentatively confirmed in 2014 by David Sinclair’s lab at Harvard University that it is a precursor to the body’s key coenzyme NAD+. NAD+ is not only an important raw material for DNA repair systems in cells, but also a key contact factor between the nucleus and mitochondria, which are responsible for energy synthesis. Meanwhile, the content of NAD+ in human body is closely related to the activity of sirtuins protein family, which can prolong life and inhibit aging.

However, NAD+ cannot be absorbed directly by cells. Therefore, scientists have discovered the precursor can be absorbed by the cells use NAD + – NMN. Oral NMN will quickly in 10 minutes to reach the blood, and gradually increase the levels of NAD + in 30 minutes! NMN can effectively compensate for the decrease of NAD+ content caused by aging, and significantly inhibit the decrease of metabolism, weight gain and osteoporosis. In addition, it has been found that NMN can effectively prevent retinopathy caused by aging and improve neurological function. These findings make NMN rapidly become a research hotspot in the field of aging medicine. Nearly 100 papers have been published in Cell, Nature, Science and other prestigious academic journals detailing its efficacy and mechanism of action. As recently reported by Cell (2018), NMN successfully reversed vascular death and muscle atrophy in elderly animals, greatly enhancing exercise endurance. The physical strength and explosive power of the older animals treated with NMN was 60% higher than that of the non-treated animals of the same age, even exceeding the level of young people. Most surprising of all, the recovery of NAD+ by oral NMN extended the life span of laboratory animals similar to the human system by more than 30%. The physical strength and explosive power of the older animals treated with NMN was 60% higher than that of the non-treated animals of the same age, even exceeding the level of young people. Most surprising of all, the recovery of NAD+ by oral NMN extended the life span of laboratory animals similar to the human system by more than 30%. The physical strength and explosive power of the older animals treated with NMN was 60% higher than that of the non-treated animals of the same age, even exceeding the level of young people. Most surprising of all, the recovery of NAD+ by oral NMN extended the life span of laboratory animals similar to the human system by more than 30%.

From 2016 to 2018, Japanese research institutions, including Harvard University, The University of Washington and Keio University, separately evaluated the anti-aging effects of NMN in detail. These include the prospect of reversing muscle atrophy and improving physical fitness, inhibiting age-related cognitive decline, reversing vascular death and protecting cardiovascular and cerebrovascular function. The results show that NMN has remarkable effect on inhibiting all aspects of aging.

1. What are NMN and NAD+?

NMN stands for nicotinamide mononucleotide, a molecule naturally present in all life forms. At the molecular level, it is a ribonucleotide, the basic structural unit of nucleic acid RNA. On the structure, the groups by nicotinamide molecules, RNA, and phosphate groups. NMN is a direct precursor of the essential molecule nicotinamide adenine dinucleotide (NAD+) and is considered to be a key component in increasing the level of NAD+ in cells. Although NAD+ is an essential coenzyme for life and cellular function. Enzymes are catalysts that make biochemical reactions possible. Coenzymes are the “helper” molecules that enzymes need to function. The NAD+ molecule itself is too large to be completely degraded in the gastrointestinal tract. Therefore, adding NAD + itself is invalid.

NMN enters the body as NAD+ and plays an important role in energy and substance metabolism. In terms of the tricarboxylic acid cycle, the tricarboxylic acid cycle is the final metabolic pathway of the three major nutrients (carbohydrates, lipids, and amino acids) in the human body. It is also the center of metabolic links between carbohydrates, lipids and amino acids. The tricarboxylic acid cycle provides a lot of energy for the organism and is the energy hub of the organism. NAD+ has a fundamental impact on human health, but with age, the amount of NAD+ in human body gradually decreases, and the communication between mitochondria and nucleus is impaired. So supplementing NMN is the key to maintaining a long and youthful body.

2. What are the main functions of NAD+?

1) aging

NAD+ is the fuel that helps sirtuins maintain genomic integrity and promote DNA repair. Just as a car cannot run without fuel, activation of sirtuins requires NAD+. Animal studies have shown that increased levels of NAD+ activate deacetylase and extend the lifespan of yeast, worms and mice. While animal studies have shown promising results on anti-aging properties, scientists are still studying how those results translate to humans.

2) Metabolic disorders

NAD+ is one of the keys to maintaining healthy mitochondrial function and stable energy output. Aging and a high-fat diet reduce levels of NAD+ in the body. Studies have shown that taking NAD+ enhancer mitigated diet-related and age-related weight gain in mice and improved their exercise ability, even in older mice. Other studies have even reversed the effects of diabetes in female mice, showing new strategies to combat metabolic disorders such as obesity.

3) Heart function

Increased NAD+ levels protect the heart and improve cardiac function. High blood pressure can cause the heart to widen and arteries to become blocked, which can lead to a stroke. In mice, the NAD+ enhancer replenished NAD+ levels in the heart and prevented heart damage due to inadequate blood flow. Other studies have shown that NAD+ enhancers protect mice from abnormally enlarged hearts.

4) Neurodegeneration

In mice with Alzheimer’s disease, increasing NAD+ levels reduced protein accumulation, which disrupted cellular communication in the brain and improved cognitive function. Boosting NAD+ also protects brain cells from dying when there is not enough blood to the brain. Many animal model studies have raised new prospects for helping the brain age healthily, defending against neurodegeneration and improving memory.

5) Immune system

As adults age, their immune systems decline, making people more susceptible to illness and making it harder for people to recover from illnesses like seasonal flu and even COVID-19. Recent studies have shown that NAD+ levels play an important role in regulating inflammation and cell survival during immune response and aging. This study highlights the therapeutic potential of NAD+ for immune dysfunction.

3. NMN is extracted from what material? Is the source safe and reliable?

A variety of fruits, vegetables, fungi and animals contain a certain amount of NMN. Through these raw materials (such as truffle, avocado, broccoli, yeast powder, pomegranate, edamame, tomato, mushroom, etc.) using the United States advanced biological enzyme method (a green technology, non-toxic and harmless, equivalent to imitate the human body catalytic enzyme working process), can be further separated and prepared.

4. What are the main applications of NMN products?

1) Keep cell energy levels at a young level. NMN plays an important role in cell energy production.

2) against age-related metabolic decline. The effect of NMN supplementation goes beyond increasing NAD+ production.

3) The circulatory system carries oxygen-rich blood, exchanges heat and nutrients, and removes waste products from all organs and systems in the body.

4) Studies on the anti-aging properties of NMN suggest that the concept of aging as an irreversible process may no longer be absolute.

5. Citrus flavonoids

Numerous studies have shown that citrus flavonoids are effective antioxidants and can act synergistically with vitamin C. Researchers found that increasing the intake of bioflavonoids reduced the damage caused by free radicals. The antioxidant and anti-inflammatory effects of citrus flavonoids have been shown to boost the body’s metabolism, circulatory, cognitive and joint health. In addition, citrus flavonoids can balance immune cell activity and promote immune response and respiratory health.

6. Grape seeds are rich in anthocyanins; The main features include:

1) Skin protection/Sun protection: Anthocyanins are natural sunscreens that protect the skin from uv rays. In experiments, the sun has been found to kill 50 percent of human skin cells. But about 85 percent of skin cells can survive if protected with anthocyanins.

2) cancer: the role of anthocyanins to remove free radicals can prevent cancer cell proliferation, which protect more healthy cells from the cancer cells.

3) Improve vision: The anthocyanins in blueberries can promote the regeneration of rhodopsin in retinal cells, prevent severe myopia and retinal detachment, and improve vision.

4) Anti-radiation: Anthocyanins also have anti-radiation effects. The color of anthocyanins changes depending on pH. Most anthocyanins have good photothermal and pH stability. Anthocyanins are essential to human exposure to sunlight and electrical radiation.

7. L-theanine

First found in the natural plant tea. It is a unique free amino acid that has calming and relaxing effects on nerves. L-theanine is different from ordinary sedatives. It is a unique free amino acid that acts as a relaxant, promoting relaxation without causing drowsiness or other side effects. Theanine also supports healthy cardiovascular function through its relaxing effects and anti-aging properties.

8. Pure Marine collagen peptide powder

USES the high quality fish raw material, extracted by special protease degradation. Marine active peptide is small in molecular weight, rich in a variety of amino acids, digestion and absorption ability. Experts point out that Marine protein peptide has the effect of promoting cell growth. The effect on skin health is mainly reflected in moisturizing, anti-aging, whitening and other aspects. Among them, anti-oxidation, anti-wrinkle, light protection, tyrosinase inhibitors are more prominent.

Caution: It is not suitable for pregnant women, nursing women and people under 18 years old.